Cigall Kadoch

mSWI/SNF complex inhibition sensitizes KRAS-mutant lung cancers to targeted therapies via epithelial-mesenchymal subversion

This study shows that inhibiting mSWI/SNF complexes enhances the effectiveness of KRAS inhibitors in lung cancers by reversing epithelial-mesenchymal transition resistance.

A SWI/SNF-specific Ig-like domain, SWIFT, is a transcription factor binding platform

The paper identifies SWIFT, a SWI/SNF subunit domain that mediates transcription factor interactions, showing its role in chromatin targeting and cancer cell proliferation.

Shifted assembly and function of mSWI/SNF family subcomplexes underlie targetable dependencies in dedifferentiated endometrial carcinomas

This study identifies shifted mSWI/SNF subcomplex stoichiometry in DDEC/UEC cancers and shows that SMARCA4/2 inhibitors reduce tumor growth and synergize with chemotherapy.

Functional consequences of genetic risk for neuropsychiatric conditions at chr22q

The paper identifies chr22q as a regulatory hub where genetic risk for neuropsychiatric conditions is associated with coordinated gene expression downregulation in brain tissue.

Molecular grammars of intrinsically disordered regions that span the human proteome

The paper introduces GIN, a resource that decodes molecular grammars of human intrinsically disordered regions (IDRs) and identifies their functional roles in biological processes and disease.

Arid1a loss potentiates pancreatic β-cell regeneration through activation of EGF signaling

This study shows that Arid1a loss enhances pancreatic β-cell regeneration by activating EGF signaling, protecting against diabetes.