Amanda Fortes Francisco

Shared and divergent features of the immune response to acute and chronic Trypanosoma cruzi infection in mice revealed by cardiac transcriptomics

This study uses cardiac transcriptomics in mice to compare immune responses during acute and chronic Trypanosoma cruzi infection, identifying shared and divergent features.

Experimental Trypanosoma cruzi infection cured with a mechanistically distinct drug combination

The paper shows that a combination of GNF6702 and benznidazole can cure experimental chronic Chagas disease with shorter treatment duration and fewer side effects.

Intermittent suppressive posaconazole therapy is ineffective at mitigating cardiac and digestive tract pathologies in an experimental model of chronic Chagas disease

This study shows that intermittent posaconazole treatment does not prevent cardiac and digestive tract pathologies in a chronic Chagas disease mouse model, even with high parasite burden reduction.

Statins do not reduce the parasite burden during experimental Trypanosoma cruzi infection

This study shows statins do not reduce parasite burden in a mouse model of Trypanosoma cruzi infection, suggesting clinical trials for trypanocidal activity are unjustified.

A panel of phenotypically and genotypically diverse bioluminescent: fluorescent Trypanosoma cruzi strains as a resource for Chagas disease research

The paper describes a panel of bioluminescent and fluorescent Trypanosoma cruzi strains to study Chagas disease, enabling real-time monitoring of infection dynamics and drug screening.