Author

Sam Reffsin

University of PennsylvaniaORCID 0000-0002-3501-4491Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Organism:human· 1 Assay:imaging· 1 Approach:statistical model· 1

Frequent Co-Authors

Arjun RajiD· 2 shared Ian P. DardaniiD· 2 shared Naveen JainiD· 2 shared Yogesh GoyaliD· 2 shared Aoife O’FarrelliD· 1 shared Benjamin L. EmertiD· 1 shared Christopher J. CoteiD· 1 shared Connie JiangiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBioinformatics

Arjun RajORCID

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2 papers

Recent·Most cited

Piscis: a novel loss estimator of the F1 score enables accurate spot detection in fluorescence microscopy images via deep learning

Zijian Niu, Aoife O’Farrell, Jingxin Li, Sam Reffsin, Naveen Jain, Ian P. Dardani, Yogesh Goyal, Arjun Raj

Piscis uses a novel loss function to improve spot detection in RNA FISH images, outperforming existing methods without manual parameter tuning.

Cell Systems · Nov 1, 2025Peer-reviewedBioinformatics

Retrospective identification of intrinsic factors that mark pluripotency potential in rare somatic cells

Naveen Jain, Yogesh Goyal, Margaret C. Dunagin, Christopher J. Cote, Ian A. Mellis, Benjamin L. Emert, Connie Jiang, Ian P. Dardani, Sam Reffsin, Miles J. Arnett, Wenli Yang, Arjun Raj

The paper identifies molecular factors that mark pluripotency potential in rare somatic cells by analyzing fibroblast reprogramming efficiency.

Cell Systems · Feb 1, 2024Peer-reviewedSystems Biology