Author
University of PennsylvaniaORCID 0000-0002-9130-3853Unclaimed ORCID profile · follow to get notified of new preprints
7 papers
Recent·Most cited
Naveen Jain, Yogesh Goyal, Margaret C. Dunagin, Christopher J. Cote, Ian A. Mellis, Benjamin L. Emert, Connie Jiang, Ian P. Dardani, Sam Reffsin, Miles J. Arnett, Wenli Yang, Arjun Raj
The paper identifies molecular factors that mark pluripotency potential in rare somatic cells by analyzing fibroblast reprogramming efficiency.
Cell Systems · Feb 1, 2024Peer-reviewedSystems Biology
Kate L. Thomson, Connie Jiang, Ebony Richardson, Dominik Sebastian Westphal, Tobias Burkard, Cordula Maria Wolf, Matteo Vatta, Steven M. Harrison, Jodie Ingles, Connie R. Bezzina, Brett M. Kroncke, Jamie I. Vandenberg, Chai‐Ann Ng
The paper establishes a functional patch clamp assay to classify KCNH2 variants in LQTS, using Z-scores to inform ACMG criteria and correlate with clinical scores.
Human Genetics and Genomics Advances · Jan 19, 2024Peer-reviewedGenetic & Genomic Medicine
Lee P. Richman, Yogesh Goyal, Connie Jiang, Arjun Raj
ClonoCluster combines clonal origin and transcriptome data to create hybrid clusters, revealing biologically relevant markers across six datasets.
Cell Genomics · Jan 12, 2023Peer-reviewedBioinformatics
Connie Jiang, Ebony Richardson, Jessica Farr, Adam Parker Hill, Rizwan Ullah, Brett M. Kroncke, Steven M. Harrison, Kate L. Thomson, Jodie Ingles, Jamie I. Vandenberg, Chai‐Ann Ng
This study uses a high-throughput patch-clamp assay to reclassify KCNH2 variants of uncertain significance, providing evidence for clinical interpretation.
The American Journal of Human Genetics · Jun 9, 2022Peer-reviewedGenetics
Connie Jiang, Yogesh Goyal, Naveen Jain, Qiaohong Wang, Rachel Truitt, Allison Coté, Benjamin L. Emert, Ian A. Mellis, Karun Kiani, Wenli Yang, Rajan Jain, Arjun Raj
The paper investigates cell type determination during cardiac differentiation of hiPS cells, finding that cell type specification begins shortly after seeding and is cell-autonomous.
Genome biology · Apr 5, 2022Peer-reviewedGenomics
Eastman M. Lewis, Genevieve Stein-O’Brien, Alejandra V. Patino, Romain Nardou, Cooper D. Grossman, Matthew P. Brown, Bidii Bangamwabo, Ndeye Ndiaye, Daniel Giovinazzo, Ian P. Dardani, Connie Jiang, Loyal A. Goff, Gül Dölen
The paper identifies that parvocellular oxytocin neurons are critical for autism-related social reward behavior and show enrichment of autism risk genes in these neurons.
Neuron · Oct 27, 2020Peer-reviewedNeuroscience
Benjamin L. Emert, Christopher J. Cote, Eduardo A. Torre, Ian P. Dardani, Connie Jiang, Naveen Jain, Sydney M. Shaffer, Arjun Raj
The paper identifies rare cell states in melanoma that contribute to drug resistance by analyzing single-cell gene expression and signaling dynamics.
bioRxiv · Mar 18, 2020 · PreprintSystems Biology