Aoife O’Farrell

This study shows that environmental branched-chain amino acids regulate ASC translation and NLRP3 inflammasome assembly through mTOR-dependent translational bursting.

Piscis uses a novel loss function to improve spot detection in RNA FISH images, outperforming existing methods without manual parameter tuning.

The paper shows that viral resistance in human skin cells is inherited through cellular lineages and preserved across generations.

This study shows that innate immune memory in macrophages is stimulus-specific, with distinct phenotypic and epigenetic responses depending on the initial training stimulus.

The paper shows melanoma cells develop therapy resistance through AP-1-mediated cellular memories that encode transient gene expression and chromatin changes.