Ian P. Dardani

Piscis uses a novel loss function to improve spot detection in RNA FISH images, outperforming existing methods without manual parameter tuning.

The paper identifies molecular factors that mark pluripotency potential in rare somatic cells by analyzing fibroblast reprogramming efficiency.

The paper shows that resistant fates in cancer cells are predetermined by intrinsic molecular differences, not microenvironmental factors, and can be influenced by drug type and dose.

The paper identifies that parvocellular oxytocin neurons are critical for autism-related social reward behavior and show enrichment of autism risk genes in these neurons.

The paper identifies rare cell states in melanoma that contribute to drug resistance by analyzing single-cell gene expression and signaling dynamics.