Heterozygous deletion of SYNGAP enzymatic domains in rats causes selective learning, social and seizure phenotypes
Danai Katsanevaki, SM Till, Ingrid Buller‐Peralta, TC. Watson, MS. Nawaz, Daisy Arkell, S. Tiwari, Vijayakumar Kapgal, Shyam S. Biswal, JAB. Smith, NJ. Anstey, Lindsay A. M. Mizen, Nicholas Perentos, MW. Jones, MA Cousin, , Peter C. Kind
This study creates a rat model with SYNGAP enzymatic domain deletion, showing learning, social, and seizure deficits in heterozygous animals.
bioRxiv · Oct 14, 2020 · PreprintNeuroscience