Alfredo Gonzalez‐Sulser

This paper shows that presynaptic filopodia, driven by activity, calcium, and actin, physically modulate membrane mechanics to enhance synchronous neurotransmission and contribute to seizure generation.

This paper develops a cross-species deep learning model for sleep staging in humans and rodents, achieving high accuracy without retraining.

This study characterizes a Grin2b heterozygous knockout rat model, revealing seizure and sleep-wake abnormalities, and tests the efficacy of two antiseizure drugs.

RatDISCO is a tissue-clearing protocol for adult rat brains that enables robust immunolabeling and detection of neuronal subtypes, glial cells, and vasculature with high transparency.

This study shows that neurodevelopmental processes in the cortex and thalamus can occur normally without microglia, using a genetically modified mouse model.

This study introduces a single-channel EEG artifact detection method using spectral slope, achieving high accuracy in identifying contaminated epochs in rat recordings.

This paper creates a mouse model of the EEF1A2 E122K mutation, showing early motor defects and electrographic seizures, with insights into its pathogenic mechanisms.

This study shows that a mutation in DNM1 causes epilepsy by disrupting synaptic vesicle endocytosis, and that a drug can reverse these effects in a mouse model.

This study analyzes EEG brain state distribution and connectivity in SYNGAP1 mutant rats, finding altered state dynamics and reduced connectivity during sleep spindles.

This study creates a rat model with SYNGAP enzymatic domain deletion, showing learning, social, and seizure deficits in heterozygous animals.