Mitochondrial Dysfunction Drives Age-Related Degeneration of the Thoracic Aorta
Arjune Dhanekula, Benjamin R. Harrison, Gavin A. Pharaoh, Aurora Mattson-Hughes, Stefano Tarantini, Rudolph S. Stuppard, Scott C. DeRoo, Christopher R. Burke, Billiana Hwang, Jay D. Pal, Michael S. Mulligan, David Joseph Marcinek
This study shows that mitochondrial dysfunction contributes to aortic aging and that treatment with elamipretide improves mitochondrial function and reduces inflammation in aged mice.
GeroScience · Nov 13, 2025Peer-reviewedCell Biology