David Joseph Marcinek

This study isolates podocyte mitochondria from mice to show they have higher respiratory capacity than tubule mitochondria, with age- and sex-dependent differences.

This study shows that mitochondrial dysfunction contributes to aortic aging and that treatment with elamipretide improves mitochondrial function and reduces inflammation in aged mice.

This study shows that inducible SOD2 knockdown in mouse skeletal muscle reduces metabolic flexibility by impairing pyruvate oxidation, with reversible effects upon recovery.

The paper uses cross-linking to study mitochondrial interactome changes in aging mouse muscle, finding age-related shifts in protein interactions linked to functional decline.

The paper detects age-related tissue-specific accumulation of mtDNA mutations in mice and shows oxidative damage mutations are reduced with treatment.

The paper identifies a mutational gradient in mtDNA that correlates with replication and influences mutation accumulation and genome composition.

This study compares high and low intensity muscle stimulation on Nrf2-mediated redox stress responses in mouse skeletal muscle, finding intensity-dependent activation of Nrf2-ARE binding and downregulation of Keap1.

This study identifies SS-31 interacting proteins in mitochondria using chemical cross-linking and mass spectrometry, revealing their roles in ATP production and 2-oxoglutarate metabolism.