Real-time capture of σN transcription initiation intermediates reveals mechanism of ATPase-driven activation by limited unfolding
Andreas U. Müller, N.Christine Molina, B. Tracy Nixon, Seth Andrew Darst
The paper uses structural and biochemical analysis to show that ATPase-driven translocation of σN-RI through a DNA bubble activates transcription initiation by disrupting inhibitory structures.
Nature Communications · Aug 4, 2025Peer-reviewedBiochemistry