Author

N.Christine Molina

Rockefeller UniversityORCID 0009-0007-9006-214XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Organism:E. coli· 1 Approach:microscopy & imaging analysis· 1 Research Focus:synaptic & neural circuits· 1

Frequent Co-Authors

Andreas U. Müller· 2 shared Seth Andrew DarstiD· 2 shared B. Tracy NixoniD· 1 shared Brandon F. MaloneiD· 1 shared Bridget O CarragheriD· 1 shared Clinton S. PotteriD· 1 shared Edward T. EngiD· 1 shared James CheniD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersBiochemistry

Andreas U. Müller

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2 papers

Recent·Most cited

BiochemistryNature CommunicationsPeer-reviewedAug 4, 2025

Real-time capture of σN transcription initiation intermediates reveals mechanism of ATPase-driven activation by limited unfolding

Andreas U. Müller, N.Christine Molina, B. Tracy Nixon, Seth Andrew Darst

The paper uses structural and biochemical analysis to show that ATPase-driven translocation of σN-RI through a DNA bubble activates transcription initiation by disrupting inhibitory structures.

3 citations

experimental assaychromatin & epigenetic regulation

𝕏 PostBluesky

BiophysicsNature Structural & Molecular BiologyPeer-reviewedJul 1, 2024

Early intermediates in bacterial RNA polymerase promoter melting visualized by time-resolved cryo-electron microscopy

Ruth M. Saecker, Andreas U. Müller, Brandon F. Malone…·Seth Andrew Darst

This study uses time-resolved cryo-EM to visualize early intermediates in bacterial RNA polymerase promoter melting, revealing key steps in the formation of the transcription-competent open complex.

17 citations

E. colicryo-EM

𝕏 PostBluesky