Andreas U. Müller

ppGpp regulates transcription elongation via direct and indirect inputs to RNA polymerase pausing and nucleotide addition

This study investigates how ppGpp regulates RNA polymerase pausing and nucleotide addition through allosteric effects and GTP competition in E. coli.

Structural principles of transcriptional collisions

This study uses cryo-EM to visualize E. coli RNAP collisions with roadblocks and other RNAPs, revealing structural changes and mechanisms of collision resolution.

Real-time capture of σN transcription initiation intermediates reveals mechanism of ATPase-driven activation by limited unfolding

The paper uses structural and biochemical analysis to show that ATPase-driven translocation of σN-RI through a DNA bubble activates transcription initiation by disrupting inhibitory structures.

Structure and functional implications of WYL-domain-containing transcription factor PafBC involved in the mycobacterial DNA damage response

The paper determines the crystal structure of PafBC, a mycobacterial transcription factor with a WYL domain, and suggests RNA binding activates it through structural analysis and mutational screening.