Author

James S.K. Sham

Johns Hopkins UniversityORCID 0000-0002-3571-8712Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

Arijit RoyiD· 1 shared Mi-Kyung ShiniD· 1 shared Omkar Padel· 1 shared Samhita Gudapati· 1 shared Vsevolod Y. PolotskyiD· 1 shared Wan-Yee Tang· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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6 top collaborators · 15 mutual co-author links

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1 shared paperPhysiology

Arijit RoyORCID

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1 paper

Recent·Most cited

Epigenetic Silencing of Carotid Body TRPM7 Attenuates Hypertension in Obese Mice

Mi-Kyung Shin, Arijit Roy, Omkar Padel, Samhita Gudapati, James S.K. Sham, Wan-Yee Tang, Vsevolod Y. Polotsky

This study shows that reversing DNA methylation at the Trpm7 promoter in carotid bodies of obese mice reduces hypertension by decreasing Trpm7 expression and nerve activity.

bioRxiv · Mar 7, 2026 · PreprintPhysiology