Vsevolod Y. Polotsky

This study shows leptin alleviates obesity hypoventilation by activating serotonergic neurons in the medullary raphe that innervate hypoglossal motoneurons.

This study shows setmelanotide reduces opioid-induced respiratory depression in mice without reversing analgesia.

This study shows that reversing DNA methylation at the Trpm7 promoter in carotid bodies of obese mice reduces hypertension by decreasing Trpm7 expression and nerve activity.

This study shows oxytocin improves survival and respiratory function in rats with opioid-induced respiratory depression caused by fentanyl or fentanyl-xylazine combinations, outperforming naloxone in some cases.

This study identifies OXT receptor expression in brainstem cardiac vagal neurons and shows that OXT selectively activates DMNX CVNs to induce bradycardia.