Author

Rajendra Prasad Settem

University at Buffalo, State University of New YorkORCID 0000-0002-3577-7675Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

Alejandro Escobar· 1 shared Edwin J OvalleiD· 1 shared Jason G. KayiD· 1 shared Michelle Panasiewicz· 1 shared Sarah MetcalfeiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 10 mutual co-author links

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1 shared paperImmunology

Alejandro Escobar

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1 paper

Recent·Most cited

Polymicrobial-driven NLRP6 inflammasome regulates IL-1β production and alveolar bone loss in a murine model of periodontitis

Sarah Metcalfe, Rajendra Prasad Settem, Edwin J Ovalle, Michelle Panasiewicz, Alejandro Escobar, Jason G. Kay

This study shows that NLRP6 inflammasome activation by polymicrobial interactions drives IL-1β production and alveolar bone loss in a mouse model of periodontitis.

PLoS Pathogens · Sep 15, 2026Peer-reviewedImmunology