Alexander B. Alleman

Life on leaves left a lasting mark on the Methylobacterium core genome

The study examines the core genome evolution of Methylobacterium to show that genes related to phyllosphere adaptation show greater evolutionary discordance, suggesting horizontal gene transfer.

Evolutionary Integration of a Foreign Aromatic Catabolic Pathway Drives Metabolic Trade-offs in Methylobacterium extorquens PA1

This study shows how a foreign aromatic catabolic pathway integrates with central metabolism in Methylobacterium extorquens, leading to substrate-specific metabolic trade-offs and cross-adaptation.

Storage polymer polyhydroxybutyrate promotes recovery and limits phenotypic heterogeneity in regrowth from carbon starvation in Methylobacterium extorquens

This study shows that PHB improves survival and reduces phenotypic heterogeneity during carbon starvation in Methylobacterium extorquens, even under extreme osmotic conditions.

Microbial Cell-Adaptive Segmentation in Quantitative Phase Imaging

The paper introduces mCAS, a segmentation framework for QPI that outperforms existing methods in accuracy and speed without requiring training data or specialized hardware.

Engineered Methylobacterium extorquens grows well on methoxylated aromatics due to its formaldehyde metabolism and stress response

This study engineers Methylobacterium extorquens to grow on methoxylated aromatics by enhancing formaldehyde detoxification and stress response, enabling robust growth without formaldehyde accumulation.