Akorede L. Seriki

Evolutionary Integration of a Foreign Aromatic Catabolic Pathway Drives Metabolic Trade-offs in Methylobacterium extorquens PA1

This study shows how a foreign aromatic catabolic pathway integrates with central metabolism in Methylobacterium extorquens, leading to substrate-specific metabolic trade-offs and cross-adaptation.

Engineered Methylobacterium extorquens grows well on methoxylated aromatics due to its formaldehyde metabolism and stress response

This study engineers Methylobacterium extorquens to grow on methoxylated aromatics by enhancing formaldehyde detoxification and stress response, enabling robust growth without formaldehyde accumulation.