Endogenous fine-mapping of functional regulatory elements in complex genetic loci
Ke Zhao, Yao Zhou, Chengyue Wu, Jianhua Wang, Hongcheng Yao, Xin Cheng, Lin Zhao, Wei Wang, Xinlei Chu, Xianfu Yi, Yupeng Chen, Miaoxin Li, Wange Lu, Kexin Chen, Pak Chung Sham, Mulin Jun Li
The paper identifies causal regulatory elements in complex genetic loci using CRISPR perturbations and shows that many causal variants lack classical epigenetic markers.
bioRxiv · May 6, 2023 · PreprintGenomics