Debnath Pal

Genetic Expectations in Inheritance: A Probabilistic Algebraic Framework

This paper introduces a probabilistic algebraic framework for modeling inheritance patterns, enabling the computation of genetic expectations and modular simulation of multi-locus inheritance processes.

Combined analysis of somatic mutations and gene expression reveals nuclear speckles-associated enhanced stemness in gingivobuccal carcinoma under DNA damage response

The paper integrates somatic mutations and gene expression in OSCC-GB to identify SON gene variants linked to enhanced stemness and disease progression under DNA damage response.

Telomere-to-telomere assembly by preserving contained reads

The paper introduces RAFT, an assembly algorithm that reduces gaps in telomere-to-telomere genomes by managing contained reads, showing improved performance on real datasets.

A Consensus Model of Glucose-Stimulated Insulin Secretion in the Pancreatic beta-Cell

The paper develops a consensus model of glucose-stimulated insulin secretion in pancreatic beta-cells using a systematic workflow, showing glucose-dependent increases in glycolytic intermediates and ATP/ADP ratios drive insulin secretion.

A graph-based framework for multi-scale modeling of physiological transport

The paper introduces a graph-based framework for modeling physiological transport across scales, validated with COMSOL simulations and applied to glucose dynamics in islet vasculature.

Spike protein fusion loop controls SARS-CoV-2 fusogenicity and infectivity

This study identifies the unique structural and physicochemical features of the SARS-CoV-2 Spike protein's fusion loop that enhance its fusogenicity and infectivity compared to other coronaviruses.