Author

Edward S. Wickstead

Queen Mary University of LondonORCID 0000-0002-3593-1222Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Simon McArthuriD· 3 shared C.S. BiggsiD· 2 shared Stephen J. GettingiD· 2 shared Bradley ElliottiD· 1 shared Egle SolitoiD· 1 shared Husnain A. Karim· 1 shared Roberta E. Manuel· 1 shared Rodrigo Azevedo LoiolaiD· 1 shared

Activity by Year

2019-2020 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 16 mutual co-author links

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3 shared papersNeuroscience

Simon McArthurORCID

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintJul 9, 2020

Activation of the pro-resolving receptors Fpr2/3 attenuate lipopolysaccharide-induced inflammatory microglial activation

Edward S. Wickstead, Bradley Elliott, C.S. Biggs…·Simon McArthur

This study shows that activating Fpr2/3 receptors reduces LPS-induced inflammation in microglia by inhibiting NFκB and promoting resolution.

2 citations

mouseexperimental assay

NeuroscienceOxidative Medicine and Cellular LongevityPeer-reviewedJun 15, 2020

Reversal of β-amyloid induced microglial toxicity in vitro by activation of Fpr2/3

Edward S. Wickstead, Husnain A. Karim, Roberta E. Manuel…·Simon McArthur

This study shows that activating Fpr2 with QC1 reverses β-amyloid-induced microglial toxicity in vitro by reducing ROS production and metabolic shifts.

20 citations

mousebulk RNA-seq

NeuroscienceFrontiers in EndocrinologyPeer-reviewedJun 26, 2019

Estrogen promotes pro-resolving microglial behaviour and phagocytic cell clearance through the actions of annexin A1

Rodrigo Azevedo Loiola, Edward S. Wickstead, Egle Solito, Simon McArthur

This study shows estrogen promotes microglial pro-resolving behavior and phagocytosis via AnxA1, suggesting potential therapeutic use of selective estrogen receptor ligands for neuroinflammation.

57 citations

mouseexperimental assay