Simon McArthur

This study shows that repeated brief isoflurane anaesthesia causes sex-dependent behavioural, cerebrovascular, and microglial changes in mice.

This study shows p-cresol sulfate impairs the blood-brain barrier via EGFR activation and demonstrates EGFR blockade prevents this damage in vitro.

This study shows that p-cresol glucuronide, a host-gut microbial co-metabolite, reduces blood-brain barrier permeability and modulates brain transcriptome expression in mice.

This study shows that TMAO enhances BBB integrity and protects against inflammation, while TMA impairs BBB function and cognitive resilience in mice.

This study shows that activating Fpr2/3 receptors reduces LPS-induced inflammation in microglia by inhibiting NFκB and promoting resolution.

This study shows that activating Fpr2 with QC1 reverses β-amyloid-induced microglial toxicity in vitro by reducing ROS production and metabolic shifts.

This study identifies circulating protein aggregates as a source of ALS biomarkers and therapeutic targets by showing their enrichment with brain proteins and pathological features.

This study shows estrogen promotes microglial pro-resolving behavior and phagocytosis via AnxA1, suggesting potential therapeutic use of selective estrogen receptor ligands for neuroinflammation.

The paper investigates how propionate, a gut microbial metabolite, interacts with the blood-brain barrier through CD14-dependent and NRF2 signaling pathways, suggesting a new mechanism in the gut-brain axis.