Genetics and Epigenetics of Aldehyde Dehydrogenase (ALDH2) in Alcohol Related Liver Disease
Bhagyalakshmi Mallapura Shankarappa, Jayant Mahadevan, Pratima Murthy, Meera Purushottam, Biju Viswanath, Sanjeev Jain, Harshad C. Devarbhavi, Ashok V. Mysore
The paper examines the interaction between genetics and epigenetics at the ALDH2 locus in individuals with and without alcohol-related cirrhosis, finding lower DNA methylation in those with cirrhosis.
medRxiv · Apr 16, 2021 · PreprintGenetic & Genomic Medicine