Meera Purushottam

The paper examines the prevalence of intermediate CAG repeat alleles in specific genes among different populations and identifies their association with neuromotor symptoms.

The paper analyzes allelic diversity and CAG repeat instability in HD patients from India, finding a strong inverse correlation between repeat length and age at onset, and reporting de novo expansions.

This study evaluates the predictive accuracy of polygenic scores for psychiatric disorders in an Indian population using European GWAS data, finding moderate-to-high accuracy for bipolar disorder but lower for OCD and externalizing traits.

The paper identifies APOE4 isoform-specific proteomic changes in neural precursor cells, revealing effects on RNA processing and cytoskeleton organization.

The paper identifies deleterious PLA2G6 variants in individuals with severe mental illness and suggests pharmacogenomic implications for antipsychotic drug binding.

This study uses whole exome sequencing in families with multiple affected individuals to identify rare variants in genes associated with both Mendelian and complex neuropsychiatric syndromes.

This study uses federated analysis in COINSTAC to examine functional network connectivity in adolescent brains linked to smoking and alcohol consumption, finding hypoconnectivity and reduced synchronization.

This study determines the minimum sample size needed for multisite harmonization using structural brain MRI features and shows how sample size requirements increase with site variability.

This study replicates and extends findings on valproate's effects on neural precursor cells by identifying common differentially expressed genes and enriched signaling pathways.

The paper analyzes whole exome sequencing data from individuals with severe mental illness to identify genes under positive selection and their biological functions.

The paper examines the interaction between genetics and epigenetics at the ALDH2 locus in individuals with and without alcohol-related cirrhosis, finding lower DNA methylation in those with cirrhosis.

The paper examines haplogroups at the HTT locus in an Indian population, finding significant genotype frequency differences between HD cases and controls, with Haplogroup A being predominant.

The paper examines the relationship between adverse childhood experiences (ACEs) and the age of onset of psychiatric diagnoses in individuals from families with multiple affected members.

The paper identifies two novel mutations in KCNJ10 and PI4KB in SeSAME syndrome patients and shows their functional impact on Kir4.1 channel activity.

This study investigates cellular phenotypes in bipolar disorder patients with and without lithium response using NPCs and LCLs, finding differences in mitochondrial potential, cell viability, and gene expression related to lithium response.