Pratima Murthy

This study uses whole exome sequencing in families with multiple affected individuals to identify rare variants in genes associated with both Mendelian and complex neuropsychiatric syndromes.

This study uses federated analysis in COINSTAC to examine functional network connectivity in adolescent brains linked to smoking and alcohol consumption, finding hypoconnectivity and reduced synchronization.

This study determines the minimum sample size needed for multisite harmonization using structural brain MRI features and shows how sample size requirements increase with site variability.

The paper analyzes whole exome sequencing data from individuals with severe mental illness to identify genes under positive selection and their biological functions.

The paper examines the interaction between genetics and epigenetics at the ALDH2 locus in individuals with and without alcohol-related cirrhosis, finding lower DNA methylation in those with cirrhosis.

This paper uses COINSTAC to perform decentralized VBM analysis on multi-site neuroimaging data to identify age, BMI, and smoking-related structural brain changes.

The paper examines the relationship between adverse childhood experiences (ACEs) and the age of onset of psychiatric diagnoses in individuals from families with multiple affected members.

The paper develops a database of coding variations from the Indian population to aid in understanding genotype-phenotype correlations and disease mechanisms.