Jayant Mahadevan

This study investigates environmental and genetic factors influencing anxiety and depression in children and adolescents across three cohorts, identifying significant environmental impacts and a novel SNP associated with the disorders.

This study evaluates the predictive accuracy of polygenic scores for psychiatric disorders in an Indian population using European GWAS data, finding moderate-to-high accuracy for bipolar disorder but lower for OCD and externalizing traits.

This study uses whole exome sequencing in families with multiple affected individuals to identify rare variants in genes associated with both Mendelian and complex neuropsychiatric syndromes.

This study determines the minimum sample size needed for multisite harmonization using structural brain MRI features and shows how sample size requirements increase with site variability.

The paper analyzes whole exome sequencing data from individuals with severe mental illness to identify genes under positive selection and their biological functions.

The paper examines the interaction between genetics and epigenetics at the ALDH2 locus in individuals with and without alcohol-related cirrhosis, finding lower DNA methylation in those with cirrhosis.

The paper examines the relationship between adverse childhood experiences (ACEs) and the age of onset of psychiatric diagnoses in individuals from families with multiple affected members.