Cancer BiologybioRxivPreprint
Transcriptional rewiring of NF-κB by HBZ and Fra-2 drives inflammatory chemoresistance in Tax-negative adult T-cell leukemia/lymphoma
Julie Tram, Laetitia Marty, Célima Mourouvin…·Jean‐Marie Péloponèse
This study identifies the Fra-2-NF-κB-IL-1β axis as a mechanism driving chemoresistance in Tax-negative ATL, with therapeutic targeting of IL-1 signaling restoring drug sensitivity.
DOI 10.64898/2026.09.30.755641