Jean‐Marie Péloponèse

Transcriptional rewiring of NF-κB by HBZ and Fra-2 drives inflammatory chemoresistance in Tax-negative adult T-cell leukemia/lymphoma

This study identifies the Fra-2-NF-κB-IL-1β axis as a mechanism driving chemoresistance in Tax-negative ATL, with therapeutic targeting of IL-1 signaling restoring drug sensitivity.

A new HIV-1 latency reversing agent activating HIV-Tat

This paper introduces a new HIV-1 latency reversing agent, D10, which activates HIV-1 Tat to induce viral production from latent cells.

Antagonistic regulation of HBZ splicing by hnRNPA1 and hnRNPH1 drives HTLV-1 leukemogenesis.

This paper identifies HBZ splicing regulation by hnRNPA1 and hnRNPH1 as a key driver of HTLV-1 leukemogenesis, showing that HBZ_SP1 promotes transformation and chemoresistance in ATL.

The viral oncoproteins Tax and HBZ reprogram the cellular mRNA splicing landscape

This study shows that Tax and HBZ, viral oncoproteins, alter mRNA splicing in T-cells by interacting with spliceosome components, leading to changes in cancer-related genes.