Sanghoon Lee

Systemic and local chronic inflammation and hormone disposition promote a tumor-permissive environment for breast cancer in older women

This study shows that chronic inflammation and hormonal changes in older women create a tumor-permissive environment for ER+ breast cancer by increasing local estradiol and immune dysfunction.

Endogenous Nitroalkene Exploits Dependence on Autophagy-Lysosome Pathway in PARPi-Resistant TNBC

This study identifies nitro-oleic acid (OA-NO2) as a compound that re-sensitizes PARPi-resistant TNBC cells to PARPi by targeting p62 and inhibiting autophagy.

IndepthPathway: an integrated tool for in-depth pathway enrichment analysis based on bulk and single cell sequencing data.

IndepthPathway improves pathway enrichment analysis for single-cell and bulk RNA-seq by addressing noise and low coverage issues through the WCSEA algorithm.

An integral genomic signature approach for tailored cancer targeted therapy using genome-wide sequencing data

This paper introduces iGenSig, a genomic signature method for predicting cancer therapy responses using genome-wide sequencing data, showing strong cross-dataset performance and resilience to sequencing errors.