Alexander J. Shackman

The paper challenges the canonical model of anxiety by showing that threat probability, not uncertainty, is more strongly associated with threat anticipation and EA regions.

The paper identifies convergent and selective functional zones in the insula using fMRI data, revealing a hierarchical convergence architecture across pain, appetitive, aversive, and cognitive control domains.

The paper analyzes fMRI data to investigate the role of the extended amygdala in threat processing, finding no strict functional segregation between the central nucleus and bed nucleus of the stria terminalis.

The paper identifies heightened subcortical reactivity to uncertain-threat as a predictor of future internalizing symptoms in individuals with low stress exposure.

This paper demonstrates that certain and uncertain threat anticipation recruit a shared neural circuit with distinct activation dynamics in humans.

This study investigates how social anxiety in adolescents affects neural responses to anticipated social threat, finding reduced discrimination in the bed nucleus of the stria terminalis.

The paper investigates the neural basis of neuroticism/negative emotionality by showing its association with heightened BST activation during uncertain threat anticipation, not the amygdala.

The paper links greater activation in a cingulo-opercular circuit during an anxiety-eliciting task with reduced daily stressor-related distress in individuals.

This study investigates the neural circuits involved in anticipating temporally uncertain and certain threat, revealing co-localized but functionally distinct brain regions associated with anxiety.

This study shows that acute alcohol reduces threat-related brain activity in the central extended amygdala in humans, specifically in the BST and Ce regions.

This paper evaluates spatial normalization techniques in fMRI, finding that a multi-tool T1EPI pipeline outperforms standard EPIO and T1EPI methods in precision, accuracy, and statistical power.

The paper maps the intrinsic functional connectivity of the central extended amygdala in healthy adults, revealing distinct patterns between the BST and Ce and their connections to prefrontal and subcortical regions.