Proteomic analysis identifies the E3 ubiquitin ligase Pdzrn3 as a regulatory target of Wnt5a-Ror signaling
Sara E. Konopelski, Michael W. Susman, Ryan C. Kunz, Jia Tan, Srisathya Srinivasan, Michael D. Cohen, Kyoko Okada, Helen Lamb, S. S. Choi, Edith P. Karuna, Michael K. Scales, Steven P. Gygi, Michael E. Greenberg, Hsin‐Yi Henry Ho
The paper identifies Pdzrn3 as a target of Wnt5a-Ror signaling through proteomic analysis and shows its degradation is essential for cell migration.
Proceedings of the National Academy of Sciences · Jun 16, 2021Peer-reviewedDevelopmental Biology