Helen Lamb

The Rac1 homolog CED-10 is a component of the MES-1/SRC-1 pathway for asymmetric division of the C. elegans EMS blastomere

This study identifies CED-10 as a component of the MES-1/SRC-1 pathway that regulates asymmetric division of the C. elegans EMS blastomere through actin regulation.

Proteomic analysis identifies the E3 ubiquitin ligase Pdzrn3 as a regulatory target of Wnt5a-Ror signaling

The paper identifies Pdzrn3 as a target of Wnt5a-Ror signaling through proteomic analysis and shows its degradation is essential for cell migration.

CBD-1 scaffolds two independent complexes required for eggshell vitelline layer formation and egg activation in C. elegans

The paper identifies CBD-1 as a scaffold protein in C. elegans that forms two distinct complexes for vitelline layer assembly and egg activation, revealing its multifaceted role in eggshell formation and fertilization.