Michael E. Greenberg

Bolero predicts cell-state-specific gene regulation from DNA across species by integrating cell-state embeddings and biological variables.

The paper shows that somatosensory neuron repertoires in mammals diversify through changes to conserved neuron types, enabling adaptation to different habitats and body forms.

This study identifies BAF complex interaction with FOS in regulating ASD-associated gene programs through enhancer activation and shows how genetic variants disrupt this process.

This study delivers GJB2 specifically to target cells in mouse models of DFNB1 deafness, restoring hearing function and validating the approach in nonhuman primates.

This study shows that ZMYND11 inhibits KMT2A to regulate neuronal development, and a mutation in ZMYND11 disrupts this interaction, leading to developmental and behavioral abnormalities.

The paper shows neuronal activity affects RNA stability, with HuD regulating mRNA abundance and variants linked to neurodevelopmental disorders disrupting this process.

This study identifies cell-type-specific chromatin accessibility and gene expression changes in the hippocampus following novel environment exposure using single-nucleus multiomics and bulk RNA-seq.

This study reveals the structural basis of the midnolin-proteasome pathway and shows that midnolin downregulation promotes myeloma cell survival by enhancing IRF4 expression.

The paper identifies human-specific activity-dependent genes regulated by FOS-bound enhancers, showing their role in human brain development evolution.

The paper uses human-chimpanzee tetraploid cells to identify cis-acting gene regulatory changes contributing to human neural specializations.

This study identifies cis-regulatory elements that drive motor neuron-specific gene expression in viral vectors, showing selectivity in mice and non-human primates.

The paper shows that experience during development shapes feature-selectivity in the mouse primary visual thalamus, independent of cortical feedback and dependent on retinogeniculate refinement.

This study shows that activity-induced phosphorylation of MeCP2 is critical for retinogeniculate synapse maturation during early postnatal development.

This study shows thyroid hormone remodels cortical circuits in adult mice, linking metabolic state to exploratory behavior through transcriptional changes in neurons and glia.

This study maps RNA translation dynamics in the human brain using ribosome profiling, identifying thousands of novel translation events and brain-specific microproteins linked to schizophrenia.

The paper identifies sequence variants affecting enhancer function by analyzing TF binding and activity in hybrid mice fibroblasts.

The paper identifies Pdzrn3 as a target of Wnt5a-Ror signaling through proteomic analysis and shows its degradation is essential for cell migration.

PESCA identifies cell-type-specific enhancers using ATAC- and single-cell RNA-sequencing to generate viral reagents for targeted gene manipulation in mammalian cells.

This study shows that sensory lesioning causes microglia to eliminate synapses through ADAM10 and fractalkine signaling, revealing a neuron-to-microglia pathway for synaptic remodeling.

The paper identifies cis-regulatory elements and their genetic variation in human retina, macula, and RPE using epigenomic profiling and single-nucleus RNA-seq.