Author

Hector R. Villarraga

Mayo ClinicORCID 0000-0002-3675-6948Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:electrophysiology· 1 Approach:experimental assay· 1 Research Focus:GWAS / association mapping· 1 Assay:GWAS summary statistics· 1 Approach:mechanistic / dynamical model· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

James R. CerhaniD· 2 shared Joseph S. ReddyiD· 2 shared Nadine NortoniD· 2 shared Nicholas James BoddickeriD· 2 shared Pooja Prem AdvaniiD· 2 shared Anthony C. LuehrsiD· 1 shared Chadi AyoubiD· 1 shared Fernando Berton ZanchiiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

James R. CerhanORCID

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2 papers

Recent·Most cited

Meta-analysis of genome-wide association studies of doxorubicin-induced arrhythmia identifies MMP16 and KCTD15 as risk loci

Joseph S. Reddy, Milagros Pereyra, Mohammed Tiseer Abbas, Reza Arsanjani, Isaac Prah, Nicholas James Boddicker, James R. Cerhan, Melissa C. Larson, Mwangi Raphael, Thomas Matthew Habermann, Hector R. Villarraga, Robert Alan Vierkant, Anthony C. Luehrs, Hugues Sicotte, Jan B. Egan, , Nadine Norton

This study identifies genetic risk loci for doxorubicin-induced arrhythmia through GWAS meta-analysis and validates their functional relevance in human and zebrafish models.

Circulation Genomic and Precision Medicine · Jul 29, 2026Peer-reviewedGenetic & Genomic Medicine

Functional Evaluation of TRPC6 Missense Variants in Cancer Patients via Molecular Docking Analysis Compared with Patch Clamp Electrophysiology

Ying Wu, Xiaojing Sun, Joseph S. Reddy, Pooja Prem Advani, Nicholas James Boddicker, James R. Cerhan, Hector R. Villarraga, Samuel J. Asirvatham, Ru-Xing Wang, Hon-Chi Lee, Nadine Norton, Fernando Berton Zanchi, Tong Lu

This study evaluates TRPC6 missense variants in cancer patients using molecular docking and patch clamp electrophysiology to predict functional impact and guide clinical decisions.

Journal of Biological Chemistry · May 6, 2026Peer-reviewedPhysiology