Direct Membrane Penetration of Oligoarginines by Fluorescence and Cryo-electron Microscopy Combined with Molecular Simulations
Katarína L. Baxová, Mattia I. Morandi, Nadav Scher, Patrik Kula, Ondřej Ticháček, Itay Schachter, Petro Busko, Jiřı́ Zahradnı́k, Mario Vazdar, Jovi Koikkara, Christoph Allolio, Ori Avinoam, Pavel Jungwirth
This study uses fluorescence, cryo-EM, and simulations to show how R9 peptides interact with membranes, causing structural changes like budding and stacking, and proposes a unified mechanism for their penetration.
bioRxiv · Apr 9, 2026 · PreprintBiophysics