Ori Avinoam

The paper identifies vesicular pseudopodia as fusion sites on large secretory vesicles in Drosophila salivary glands and shows their coordination with apical domains for efficient exocytosis.

This study uses fluorescence, cryo-EM, and simulations to show how R9 peptides interact with membranes, causing structural changes like budding and stacking, and proposes a unified mechanism for their penetration.

The paper introduces a GPMV-imaging platform to study receptor binding and membrane fusion in live cells, showing how membrane composition affects fusion efficiency.

This paper develops synthetic exosomes with optimized lipid profiles to enhance gemcitabine delivery in pancreatic cancer, showing improved tumor targeting and treatment efficacy.

This study shows that CHMP2A is essential for the ordered assembly of ESCRT-III proteins during cytokinetic abscission, revealing a hierarchical organization of these subunits.

The paper uses 3D cryo-imaging to show that cells clear cholesterol crystals in human atherosclerotic plaques through enzymatic esterification.

This paper introduces a correlative light and electron microscopy workflow to quantify lipid densities in membrane nanodomains and finds sphingomyelin partitions into specific endosomal structures.

This study uses high-throughput screening to identify small molecule inhibitors that block coronavirus entry, finding a novel broad-spectrum antiviral.