Autophagy maintains HEV identity and function during inflammation
Kathryn Jacobs, Yichao Hua, Apostolis Panagiotis Nikolakopoulos, Swati Gupta, Gerlanda Vella, Ana Filipa Domingues Laranjeiro, Julie Bonnereau, Mélanie Guyot, Larissa Mourão, Feyza Cansiz, Gabriele Allies, Nicolas van Baren, Sophie Lucas, Wiebke Sondermann, Florian Rambow, , Gabriele Bergers
This study shows autophagy is essential for maintaining HEV function and expansion during inflammation, ensuring proper PNAd production and lymphocyte homing.
bioRxiv · Aug 6, 2025 · PreprintCell Biology