Florian Rambow

Loss of the Y chromosome drives basal identity and metastatic potential via epigenetic reprogramming in pancreatic cancer

This study identifies LOY as a driver of aggressive PDAC through epigenetic reprogramming, linking it to EMT and metastasis, and highlights its clinical relevance as a biomarker.

Targeting Pre-existing Club-Like Cells in Prostate Cancer Potentiates Androgen Deprivation Therapy

This study identifies castration-tolerant Club-like cells in prostate cancer and shows that targeting FOSL1/AP-1 and PIM kinases reduces their progenitor properties and tumor growth.

Astrocytic PIEZO activation by heartbeat sound promotes extracellular matrix and maturation in human brain organoids

This study shows that heartbeat sound activates PIEZO channels in astrocytes, promoting extracellular matrix synthesis and neural differentiation in human brain organoids.

Multiomic profiling of a unique in-transit melanoma cohort identifies melanoma differentiation as predictor of tumor progression and therapy response

The paper identifies melanoma differentiation and immune exhaustion as predictors of tumor progression and therapy response in in-transit melanoma patients through multiomic profiling.

Autophagy maintains HEV identity and function during inflammation

This study shows autophagy is essential for maintaining HEV function and expansion during inflammation, ensuring proper PNAd production and lymphocyte homing.

Redirecting resistance evolution in BRAFV600 melanoma by inhibition of the peroxiredoxin-thioredoxin system

This study identifies KDM5B's role in regulating the PRDX/TXN ROS detoxification system in melanoma DTPs, showing that PRDX inhibition increases ROS vulnerability and delays resistance to MAPK inhibition.

Single-cell Genome-and-Transcriptome sequencing without upfront whole-genome amplification reveals cell state plasticity of melanoma subclones

This paper introduces Gtag&T-seq, a low-cost single-cell multi-omics method that reveals cell state plasticity and treatment response in melanoma subclones.

SeuratExtend: Streamlining Single-Cell RNA-Seq Analysis Through an Integrated and Intuitive Framework

SeuratExtend integrates R and Python tools with databases to streamline scRNA-seq analysis, offering enhanced visualization and functional analysis capabilities.

Single-cell gene regulatory network analysis reveals new melanoma cell states and transition trajectories during phenotype switching

The paper identifies an intermediate cell state in melanoma through single-cell RNA-seq and ATAC-seq, revealing a gene regulatory network that governs phenotype switching and potential therapeutic targets.

The lncRNA NEAT1_1 is dispensable for normal tissue homeostasis and cancer cell growth

The paper investigates the roles of NEAT1 isoforms, finding that NEAT1_1 is dispensable for tissue homeostasis and cancer cell growth, while NEAT1_2 is critical for paraspeckle formation and function.

Dynamic Erasure of Random X-Chromosome Inactivation during iPSC Reprogramming

This study investigates the dynamics of X-chromosome reactivation during mouse iPSC reprogramming, revealing hierarchical gene activation patterns and the role of chromatin regulators.

SCENIC: Single-Cell Regulatory Network Inference And Clustering

Building gene regulatory networks from scRNA-seq and clustering cells on them identifies stable states robustly to batch effects, applied to mouse and human brain and to melanoma.