Author

Lingyi Chen

Nankai UniversityORCID 0000-0002-3695-3407Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell-cell communication· 1 Assay:ChIP-seq· 1 Approach:deep learning· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Peiling NiiD· 2 shared Xiao WangiD· 2 shared Haiyang WuiD· 1 shared HanYu LuoiD· 1 shared Kailing Tang· 1 shared Li TangiD· 1 shared Li‐Feng ZhangiD· 1 shared Lihong YeiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersDevelopmental Biology

Peiling NiORCID

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3 papers

Recent·Most cited

Deep learning framework ChIANet predicts protein-mediated chromatin architecture across functional contexts

HanYu Luo, Renjie Wen, Li Tang, Lingyi Chen, Kailing Tang, Min Li

ChIANet predicts protein-mediated chromatin architectures across contexts using deep learning, revealing context-dependent reconfiguration and functional biases.

bioRxiv · Feb 25, 2026 · PreprintGenomics

Hbxip (Lamtor5) is essential for embryogenesis and regulates embryonic stem cell differentiation through activating mTORC1

Yan Qin, Peiling Ni, Qingye Zhang, Xiao Wang, Xiaoling Du, Zixi Yin, Lingling Wang, Lihong Ye, Lingyi Chen

This study shows Hbxip is essential for embryonic development and ESC differentiation by activating mTORC1 signaling.

bioRxiv · Jan 4, 2022 · PreprintDevelopmental Biology

The lupus autoantigen La is an Xist-binding protein involved in Xist folding and cloud formation

Norbert Ha, Nan Ding, Ru Hong, Rubing Liu, Xavier Roca, Yingyuan Luo, Xiaowei Duan, Xiao Wang, Peiling Ni, Haiyang Wu, Li‐Feng Zhang, Lingyi Chen

This study identifies La as an Xist-binding protein essential for X chromosome inactivation, showing its role in Xist folding and cloud formation through functional and imaging analyses.

Nucleic Acids Research · Oct 13, 2021Peer-reviewedMolecular Biology