Li‐Feng Zhang

This study identifies La as an Xist-binding protein essential for X chromosome inactivation, showing its role in Xist folding and cloud formation through functional and imaging analyses.

The paper identifies essential enhancers for pluripotency in mouse ES cells using a CRISPR-Cas9 screen and characterizes their target genes and regulatory networks.

This study uses scRNA-Seq and scATAC-Seq to show that human reprogramming occurs through asynchronous, diverse trajectories with distinct regulatory networks.

The paper introduces ASTAR-Seq, a method for parallel single-cell transcriptome and chromatin accessibility sequencing, and uses it to analyze mESCs, human cell lines, and erythroblast differentiation.