MicrobiologybioRxivPreprint
TGF-β inhibitor SB431542 suppresses coronavirus replication through multistep inhibition
Assim Verma, Garvit Kumar, Nitin Khandelwal…·Naveen Kumar
This paper shows that SB431542, a TGF-β inhibitor, suppresses SARS-CoV-2 replication through three mechanisms: disrupting ORF3a function, inhibiting lysosomal biogenesis, and blocking TGF-β-induced apoptosis, with no resistance observed after 50 generations of exposure.
DOI 10.1101/2025.03.20.644376