Le Zhang

This paper introduces MLMGCN-CVD, an annotation-free framework for predicting atherosclerotic cardiovascular disease from gut metagenomic sequences, achieving high accuracy and uncovering novel microbiome functions.

The paper identifies conserved IFN-I loci and lineage-specific expansions in amniotes, revealing convergent evolution and interchromosomal duplications contributing to IFN-I diversity.

This study identifies S100a4+ alveolar macrophages that promote lung cancer progression by enhancing angiogenesis through fatty acid metabolism in precancerous lesions.

The paper defines and maps CpG islands and their methylation status in the T2T-YAO genome, comparing it to T2T-CHM13 and finding differences in CpG density and methylation patterns.

The paper uses spatial transcriptome analysis in a mouse model of intraventricular haemorrhage to identify 3D gene expression trajectories and neural circuits involved in secondary brain injury.