Bing Li

Substitution rate variation, not hidden paralogy, drives false hybridization signal in phylogenetic network inference

The paper evaluates how substitution rate variation and hidden paralogy affect phylogenetic network inference methods, finding that rate variation causes false hybridization signals.

Locus-specific Convergent Evolution and Interchromosomal Rearrangements Contribute Type I Interferon Diversification in Amniotes

The paper identifies conserved IFN-I loci and lineage-specific expansions in amniotes, revealing convergent evolution and interchromosomal duplications contributing to IFN-I diversity.

IgG Propels Atherosclerosis by Noncanonically Activating Macrophages

This study identifies IgG's pro-atherogenic role through noncanonical activation of macrophages, independent of its classical function, by acting as a TLR4 ligand and promoting inflammation.

Hyaluronidase unlocks sequestered CEACAM5 and improves CAR T-cell therapy in colorectal cancer

This study shows that hyaluronidase improves CEACAM5 accessibility on colorectal cancer cells, enhancing CAR T-cell therapy effectiveness by reducing glycocalyx thickness and restoring sustained T-cell activation.

FABP5 in Skin Macrophages Mediates Saturated Fat-Induced IL-1β Signaling in Obesity-Associated Psoriasis Development

This study shows that saturated fats drive psoriasis via FABP5-mediated IL-1β/IL-17 signaling in skin macrophages, exacerbating obesity-associated psoriasis.

Targeting CD38 effectively prevents myelofibrosis in myeloproliferative neoplasms

This study shows that targeting CD38 in monocytes prevents myelofibrosis in MPN models and identifies CD38 as a potential biomarker and therapeutic target.

SARS-CoV-2 JN.1 reveals attenuated pathogenicity and airborne transmission

This study shows that SARS-CoV-2 JN.1 has reduced pathogenicity and airborne transmission compared to previous variants.

Structural covariation between cerebellum and cerebral cortex is atypically modulated by thalamus in autism spectrum disorder

The paper investigates structural covariation between cerebellum, thalamus, and cerebral cortex in neurotypical and ASD children, finding altered coupling patterns in ASD.

LncRNA Snhg1-driven self-reinforcing regulatory network promotes cardiomyocyte cytokinesis

This study identifies Snhg1 as a driver of stable cardiomyocyte cytokinesis through a positive feedback loop with c-Myc, improving cardiac function after myocardial infarction.

The Amyloid Structure of Mouse RIPK3 (Receptor Interacting Protein Kinase 3) in Cell Necroptosis

This study structures and functionally characterizes the mouse RIPK3 amyloid complex in necroptosis, revealing a unique N-shaped core and a structural transformation from hetero- to homo-oligomer.

A particle-filter framework for robust cryoEM 3D reconstruction

This paper introduces a particle-filter algorithm for cryoEM to improve robustness and resolution in 3D reconstruction of macromolecules.

Specific Virus-Host Genome Interactions Revealed By Tethered Chromosome Conformation Capture

The paper uses Tethered Chromosome Conformation Capture to analyze adenovirus-host genome interactions in human lung fibroblasts, finding specific and non-random interactions enriched in active chromatin regions.