Jun Yu

The paper introduces a support-based validation framework to correct assembly errors in diploid genomes using independent sequencing evidence.

The paper identifies human divergently-paired genes (DPGs) and analyzes their conservation, regulatory features, and evolutionary patterns across vertebrate lineages.

This study evaluates the impact of population-specific reference genomes on variant calling in WES data from Chinese tumor samples, finding improved accuracy with the YAO reference.

This study uses single-cell RNA sequencing to show that chronic methamphetamine exposure alters liver immune cell composition and function, with involvement of the dopamine D1 receptor.

The paper defines and maps CpG islands and their methylation status in the T2T-YAO genome, comparing it to T2T-CHM13 and finding differences in CpG density and methylation patterns.

The paper analyzes recombination patterns in Escherichia coli genomes to show extensive intra-clade recombination and reduced inter-clade recombination, establishing genetic barriers between subpopulations.

This study uses single molecule sequencing of cell-free DNA from maternal plasma to detect trisomy 13, 18, and 21 with improved sensitivity and reduced GC bias compared to NGS.

The paper resequences the E. coli genome using the GenoCare single molecule sequencing platform and shows comparable performance to the Illumina MiSeq system.