Zhihui Zhu

The paper identifies ceramide-rich extracellular vesicles as biomarkers of traumatic brain injury, showing their role in inflammation and neuronal mitochondrial dysfunction.

This paper introduces a novel reporter mouse to track astrocyte-derived extracellular vesicles and shows their cargo traffics to neuronal mitochondria in vivo.

This study shows that nSMase2 deficiency reduces ceramide and improves cognition in aged mice by mitigating oxidative stress and astrocyte activation.