Zainuddin Quadri

The paper identifies ceramide-rich extracellular vesicles as biomarkers of traumatic brain injury, showing their role in inflammation and neuronal mitochondrial dysfunction.

This paper introduces a novel reporter mouse to track astrocyte-derived extracellular vesicles and shows their cargo traffics to neuronal mitochondria in vivo.

The paper identifies citrullination of tau as a novel posttranslational modification in Alzheimer's disease and tauopathy models, showing its association with disease progression.

This study identifies GPRC6A as a key regulator of mTORC1 signaling and tau pathology in tauopathies, showing that targeting GPRC6A could reduce tau accumulation and related neurodegeneration.

This study identifies citrullination as a novel irreversible post-translational modification of TDP-43 linked to structural changes, aggregation, and pathology in TDP-43 proteinopathies.

This study shows that nSMase2 deficiency reduces ceramide and improves cognition in aged mice by mitigating oxidative stress and astrocyte activation.