3D Light Sheet Microscopy Reveals Aging Osteoarthritis-associated Joint-innervated Nerve Remodeling in Mouse Knee Joints
Paromita Kundu, Brian C. Wise, Emma G. Norris, Mark James, Yaxin Zhang, Jennifer H. Jonason, Mark R. Buckley, Whasil Lee
This study uses 3D imaging to show that aging male mice with osteoarthritis have increased nociceptive nerve remodeling linked to pain, while females show no age-related changes.
Osteoarthritis and Cartilage · Apr 23, 2026Peer-reviewedNeuroscience