Nociceptin Orphanin F/Q Pathways are Dysregulated by Stress and Modulate Reward Learning and Motivation Across Species
Diego A. Pizzagalli, Michael Tilghman Treadway, Brian D. Kangas, Benedetto Romoli, Jocelyn Breton, Michael R. Bruchas, Ann M. Graybiel, Emily Hueske, Nandkishore Prakash, Andre Der‐Avakian, Sabina Berretta, Kevin G. Bath, Davide Dulcis
This study shows that chronic stress alters Pnoc expression in reward-related brain regions and that NOPR antagonism improves reward learning and motivation in animals and humans.
bioRxiv · May 5, 2025 · PreprintNeuroscience