Ann M. Graybiel

This study shows that acute stress reorganizes neural coupling in rMDD patients during decision-making, predicting future depressive symptoms.

This study shows that dopamine signals in the striatum track slow internal states of behavioral performance, distinct from reward prediction errors, and are organized by task demands.

This study investigates the functional roles of the caudal orbitofrontal cortex (cOFC) and pregenual anterior cingulate cortex (pACC) in macaques using multimodal recordings and electrical microstimulation, finding distinct roles in decision-making and autonomic responses.

This study identifies state-dependent modulation of spiny projection neurons in a mouse Parkinson's model and shows how disrupting specific signaling pathways reduces levodopa-induced dyskinesia.

The paper uses machine learning to analyze striosome and matrix compartments in Huntington's disease model mice, revealing age-related molecular differences that may explain disease pathogenesis.

This study shows that chronic stress alters Pnoc expression in reward-related brain regions and that NOPR antagonism improves reward learning and motivation in animals and humans.

The paper investigates how dopamine and astrocytic calcium activity coordinate during behavioral breaks in mice, showing dopamine drives astrocytic activity and affects learning.

The paper identifies striosomal populations in the dorsal striatum expressing Pnoc mRNA, which are dopamine receptor D1-expressing medium spiny neurons with direct projections to midbrain dopamine neurons.

This study shows that dopamine release patterns in the dorsal striatum differ between medial and lateral regions during learning, challenging classic reinforcement learning models.

The paper develops a method to simultaneously measure dopamine and neuronal spikes in monkeys using carbon fiber electrodes and validates it for cell-type specific activity related to behavior.

The paper identifies striosomal pathways that target substantia nigra dopamine neurons, with opposite effects on movement compared to canonical pathways.

The paper investigates rhythm receptive fields in the striatum of mice performing complex movements, finding neurons sensitive to movement rhythm parameters and highlighting their role in motor coordination.

The paper examines transcriptional changes in striatal neurons in Huntington's disease, finding that striosomal SPNs are most depleted and compartmental markers are dysregulated in both mouse models and human HD.

This study shows that CB1R is essential for the postnatal development of striosome-dendron bouquets, which are critical for dopamine system connectivity, and suggests potential developmental risks from maternal use of CB1R agonists or antagonists.

This study examines the effects of repeated M4 PAM VU0152099 administration on cocaine vs. food choice in rats, finding progressive suppression of cocaine choice without rebound or lasting effects.

The paper develops a novel foraging task to study action-outcome associations in mice, revealing that striosomal neurons encode reinforcement outcomes more strongly than matrix neurons.

This study shows that microstimulation of specific prefrontal cortex regions in non-human primates induces negative decision-making by targeting striosomes in the anterior striatum.

This study identifies CalDAG-GEFI mutations causing psychomotor symptoms and bleeding in multiple species, revealing conserved signaling deficits in striatal function.

This study identifies lineage programs in radial glial progenitors that generate striosome and matrix compartments through distinct intermediate progenitors, revealing their role in striatal circuit organization.

The paper uses 2-photon imaging to show striosomes and matrix in the striatum have distinct roles in reinforcement learning by encoding reward-predicting cues and expected outcomes.