Loss of HNF1b drives pancreatic Intraductal Papillary Mucinous Neoplasms (IPMN) initiation
Diane Lorenzo, Lina Aguilera Munoz, Louis MARSTRAND-DAUCE, Anaïs Chassac, Pascal Nicole, Lingkang Meng, Laurence Heidet, Bertrand Knebelmann, Camille Pignolet, Sabrina Doblas, Alain Couvineau, Iréne Esposito, Vinciane Rebours, Rémy Nicolle, Jerome F. Cros, , Cécile Haumaître
This study shows that loss of HNF1B contributes to IPMN initiation and identifies its role as a tumor suppressor in pancreatic ductal cells.
bioRxiv · Jun 12, 2025 · PreprintPathology